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| Geregistreerd op: 13 Jan 2008 |
| Berichten: 7 |
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Onderstaande tekst komt van PubMed....
Weet niet of ik nou de enige ben die de verbanden ziet, maar alle heisa over Taxol lijkt eindelijk ergens naartoe te leiden...
Groet,
Kyle
Antifungal properties of taxol and various analogues.
Young DH, Michelotti EL, Swindell CS, Krauss NE.
Rohm and Haas Co., Research Laboratories, Spring House, Pennsylvania 19477.
The antimitotic agent taxol was tested for toxicity towards fungi from different taxonomic groups and found to be particularly active against oomycete fungi. In germinating zoospore cysts of the oomycete Phytophthora capsici the mechanism of action of taxol was shown to involve inhibition of mitosis, presumably resulting from an effect on microtubules. Various taxol analogues with deleted A-ring C-13 side chain substituents were tested for toxicity towards P. capsici and Aphanomyces cochlioides to provide insight into structural features required for activity. The importance of the side chain was shown by the much lower activity as compared to taxol of analogues lacking all or part of the side chain. The effect of stereochemistry at the C-2' position on fungitoxicity towards oomycetes was similar to that reported previously on mammalian microtubule assembly.
PMID: 1356825 [PubMed - indexed for MEDLINE] |
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